Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue DCs
Identifieur interne : 002000 ( Main/Exploration ); précédent : 001F99; suivant : 002001Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue DCs
Auteurs : Emma L. Kuan [États-Unis] ; Stoyan Ivanov [États-Unis] ; Eric A. Bridenbaugh [États-Unis] ; Gabriel Victora [États-Unis] ; Wei Wang [États-Unis] ; Ed W. Childs [États-Unis] ; Andrew M. Platt [États-Unis] ; Claudia V. Jakubzick [États-Unis] ; Robert J. Mason [États-Unis] ; Anatoliy A. Gashev [États-Unis] ; Michel Nussenzweig [États-Unis] ; Melody A. Swartz [Suisse] ; Michael L. Dustin [États-Unis] ; David C. Zawieja [États-Unis] ; Gwendalyn J. Randolph [États-Unis]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2015.
Abstract
Collecting lymphatic vessels (CLVs), surrounded by fat and endowed with contractile muscle and valves, transport lymph from tissues after it is absorbed into lymphatic capillaries. CLVs are not known to participate in immune responses. Here, we observed that the inherent permeability of CLVs allowed broad distribution of lymph components within surrounding fat for uptake by adjacent macrophages and dendritic cells (DCs) that actively interacted with CLVs. Endocytosis of lymph-derived antigens by these cells supported recall T cell responses in the fat and also generated antigen-bearing DCs for emigration into adjacent lymph nodes. Enhanced recruitment of DCs to inflammation-reactive lymph nodes significantly relied on adipose tissue DCs to maintain sufficient numbers of antigen-bearing DCs as the lymph node expanded. Thus, CLVs coordinate inflammation and immunity within adipose depots and foster the generation of an unexpected pool of APCs for antigen transport into the adjacent lymph node.
Url:
DOI: 10.4049/jimmunol.1500221
PubMed: 25917096
PubMed Central: 4433841
Affiliations:
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Kuan</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ivanov, Stoyan" sort="Ivanov, Stoyan" uniqKey="Ivanov S" first="Stoyan" last="Ivanov">Stoyan Ivanov</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Pathology & Immunology, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Bridenbaugh, Eric A" sort="Bridenbaugh, Eric A" uniqKey="Bridenbaugh E" first="Eric A." last="Bridenbaugh">Eric A. 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Randolph</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Pathology & Immunology, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A1">Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25917096</idno><idno type="pmc">4433841</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433841</idno><idno type="RBID">PMC:4433841</idno><idno type="doi">10.4049/jimmunol.1500221</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003662</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003662</idno><idno type="wicri:Area/Pmc/Curation">003661</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003661</idno><idno type="wicri:Area/Pmc/Checkpoint">001411</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001411</idno><idno type="wicri:Area/Ncbi/Merge">007315</idno><idno type="wicri:Area/Ncbi/Curation">007315</idno><idno type="wicri:Area/Ncbi/Checkpoint">007315</idno><idno type="wicri:doubleKey">0022-1767:2015:Kuan E:collecting:lymphatic:vessel</idno><idno type="wicri:Area/Main/Merge">002003</idno><idno type="wicri:Area/Main/Curation">002000</idno><idno type="wicri:Area/Main/Exploration">002000</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue DCs</title><author><name sortKey="Kuan, Emma L" sort="Kuan, Emma L" uniqKey="Kuan E" first="Emma L." last="Kuan">Emma L. Kuan</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ivanov, Stoyan" sort="Ivanov, Stoyan" uniqKey="Ivanov S" first="Stoyan" last="Ivanov">Stoyan Ivanov</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Pathology & Immunology, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Bridenbaugh, Eric A" sort="Bridenbaugh, Eric A" uniqKey="Bridenbaugh E" first="Eric A." last="Bridenbaugh">Eric A. Bridenbaugh</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple, TX 76504 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple</wicri:cityArea></affiliation></author><author><name sortKey="Victora, Gabriel" sort="Victora, Gabriel" uniqKey="Victora G" first="Gabriel" last="Victora">Gabriel Victora</name><affiliation wicri:level="2"><nlm:aff id="A5">Program in Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, The Helen L. and Martin S. Kimmel Center for Biology and Medicine, New York University School of Medicine, New York NY 10016 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Program in Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, The Helen L. and Martin S. Kimmel Center for Biology and Medicine, New York University School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple, TX 76504 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple</wicri:cityArea></affiliation></author><author><name sortKey="Childs, Ed W" sort="Childs, Ed W" uniqKey="Childs E" first="Ed W." last="Childs">Ed W. Childs</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Surgery, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple, TX 76504 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Surgery, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple</wicri:cityArea></affiliation></author><author><name sortKey="Platt, Andrew M" sort="Platt, Andrew M" uniqKey="Platt A" first="Andrew M." last="Platt">Andrew M. Platt</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Jakubzick, Claudia V" sort="Jakubzick, Claudia V" uniqKey="Jakubzick C" first="Claudia V." last="Jakubzick">Claudia V. Jakubzick</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Pediatrics, National Jewish Health, Denver, CO 80206</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Department of Pediatrics, National Jewish Health, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Mason, Robert J" sort="Mason, Robert J" uniqKey="Mason R" first="Robert J." last="Mason">Robert J. Mason</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Medicine, National Jewish Health, Denver, CO 80206</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Department of Medicine, National Jewish Health, Denver</wicri:cityArea></affiliation></author><author><name sortKey="Gashev, Anatoliy A" sort="Gashev, Anatoliy A" uniqKey="Gashev A" first="Anatoliy A." last="Gashev">Anatoliy A. Gashev</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple, TX 76504 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple</wicri:cityArea></affiliation></author><author><name sortKey="Nussenzweig, Michel" sort="Nussenzweig, Michel" uniqKey="Nussenzweig M" first="Michel" last="Nussenzweig">Michel Nussenzweig</name><affiliation wicri:level="2"><nlm:aff id="A8">Laboratory of Molecular Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Laboratory of Molecular Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name><affiliation wicri:level="1"><nlm:aff id="A9">Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Dustin, Michael L" sort="Dustin, Michael L" uniqKey="Dustin M" first="Michael L." last="Dustin">Michael L. Dustin</name><affiliation wicri:level="2"><nlm:aff id="A5">Program in Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, The Helen L. and Martin S. Kimmel Center for Biology and Medicine, New York University School of Medicine, New York NY 10016 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Program in Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, The Helen L. and Martin S. Kimmel Center for Biology and Medicine, New York University School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple, TX 76504 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Division of Lymphatic Biology, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, Temple</wicri:cityArea></affiliation></author><author><name sortKey="Randolph, Gwendalyn J" sort="Randolph, Gwendalyn J" uniqKey="Randolph G" first="Gwendalyn J." last="Randolph">Gwendalyn J. Randolph</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Pathology & Immunology, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A1">Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Gene and Cell Medicine, Graduate Program in Immunology and Immunology Institute, Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><idno type="eISSN">1550-6606</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Collecting lymphatic vessels (CLVs), surrounded by fat and endowed with contractile muscle and valves, transport lymph from tissues after it is absorbed into lymphatic capillaries. CLVs are not known to participate in immune responses. Here, we observed that the inherent permeability of CLVs allowed broad distribution of lymph components within surrounding fat for uptake by adjacent macrophages and dendritic cells (DCs) that actively interacted with CLVs. Endocytosis of lymph-derived antigens by these cells supported recall T cell responses in the fat and also generated antigen-bearing DCs for emigration into adjacent lymph nodes. Enhanced recruitment of DCs to inflammation-reactive lymph nodes significantly relied on adipose tissue DCs to maintain sufficient numbers of antigen-bearing DCs as the lymph node expanded. Thus, CLVs coordinate inflammation and immunity within adipose depots and foster the generation of an unexpected pool of APCs for antigen transport into the adjacent lymph node.</p></div></front></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Vaud</li><li>Colorado</li><li>Missouri (État)</li><li>Texas</li><li>État de New York</li></region><settlement><li>Lausanne</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Kuan, Emma L" sort="Kuan, Emma L" uniqKey="Kuan E" first="Emma L." last="Kuan">Emma L. Kuan</name></region><name sortKey="Bridenbaugh, Eric A" sort="Bridenbaugh, Eric A" uniqKey="Bridenbaugh E" first="Eric A." last="Bridenbaugh">Eric A. Bridenbaugh</name><name sortKey="Childs, Ed W" sort="Childs, Ed W" uniqKey="Childs E" first="Ed W." last="Childs">Ed W. Childs</name><name sortKey="Dustin, Michael L" sort="Dustin, Michael L" uniqKey="Dustin M" first="Michael L." last="Dustin">Michael L. Dustin</name><name sortKey="Gashev, Anatoliy A" sort="Gashev, Anatoliy A" uniqKey="Gashev A" first="Anatoliy A." last="Gashev">Anatoliy A. Gashev</name><name sortKey="Ivanov, Stoyan" sort="Ivanov, Stoyan" uniqKey="Ivanov S" first="Stoyan" last="Ivanov">Stoyan Ivanov</name><name sortKey="Jakubzick, Claudia V" sort="Jakubzick, Claudia V" uniqKey="Jakubzick C" first="Claudia V." last="Jakubzick">Claudia V. Jakubzick</name><name sortKey="Mason, Robert J" sort="Mason, Robert J" uniqKey="Mason R" first="Robert J." last="Mason">Robert J. Mason</name><name sortKey="Nussenzweig, Michel" sort="Nussenzweig, Michel" uniqKey="Nussenzweig M" first="Michel" last="Nussenzweig">Michel Nussenzweig</name><name sortKey="Platt, Andrew M" sort="Platt, Andrew M" uniqKey="Platt A" first="Andrew M." last="Platt">Andrew M. Platt</name><name sortKey="Randolph, Gwendalyn J" sort="Randolph, Gwendalyn J" uniqKey="Randolph G" first="Gwendalyn J." last="Randolph">Gwendalyn J. Randolph</name><name sortKey="Randolph, Gwendalyn J" sort="Randolph, Gwendalyn J" uniqKey="Randolph G" first="Gwendalyn J." last="Randolph">Gwendalyn J. Randolph</name><name sortKey="Victora, Gabriel" sort="Victora, Gabriel" uniqKey="Victora G" first="Gabriel" last="Victora">Gabriel Victora</name><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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